Diabetes and Sexual Dysfunction: Results From the Olmsted County Study of Urinary Symptoms and Health Status Among Men
Abstract
Purpose:
We examined the association of diabetes and domains of sexual dysfunction in a population based sample of men residing in Olmsted County, Minnesota.
Materials and Methods:
A cohort of 2,115 white men 40 to 79 years old as of January 1, 1990 was randomly selected from the Olmsted County population. Men who had a history of prostate or bladder surgery, urethral surgery or stricture, or medical or other neurological condition that could affect normal urinary function were excluded from analysis. Diabetes itself was not used as an exclusionary criterion, although those with end stage organ failure as a result of diabetes were excluded. A previously validated male sexual function index was included in the questionnaires administrated to the cohort in 1996, which consisted of 11 questions on the 5 sexual function domains of sexual drive, erectile function, ejaculatory function, sexual problem assessment and sexual satisfaction. The baseline questionnaire also included whether they had ever been diagnosed by a physician as having diabetes. Only men with regular sexual partners were included.
Results:
Individuals with diabetes at baseline had significantly greater dysfunction in all 5 sexual function domains. In multivariate adjusted analyses diabetes was significantly associated with all sexual dysfunction domains. The associations remained significant after adjusting for numerous predictors of sexual dysfunction.
Conclusions:
The presence of diabetes at baseline was significantly associated not only with erectile dysfunction but with all aspects of sexual dysfunction, including sexual drive, ejaculatory function, sexual problems and sexual satisfaction in this population based sample of men residing in Olmsted County.
References
- 1 : Erectile dysfunction and comorbid diseases, androgen deficiency, and diminished libido in men. J Am Osteopathic Assoc2004; 104: S9. Google Scholar
- 2 : Diabetic sexual dysfunction: a comparative study of 160 insulin treated diabetic men and women and an age-matched control group. Arch Sex Behavior1981; 10: 493. Google Scholar
- 3 : Optimizing treatment for diabetes mellitus induced erectile dysfunction. J Urol2003; 170: S35. Link, Google Scholar
- 4 : Erectile dysfunction in the patient with diabetes mellitus. Am J Managed Care2004; 10: S3. Google Scholar
- 5 : Vascular damage induced by type 2 diabetes mellitus as a risk factor for benign prostatic hyperplasia. Diabetologia2005; 48: 784. Google Scholar
- 6 : Pathophysiology of diabetic sexual dysfunction. J Endocrinol Invest2003; 26: 65. Google Scholar
- 7 : Textbook of Sexual Medicine. Boston: Little, Brown1979. Google Scholar
- 8 : Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol1994; 151: 54. Link, Google Scholar
- 9 : Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study. J Urol2000; 163: 460. Link, Google Scholar
- 10 : Distribution of the Brief Male Sexual Inventory in community men. Int J Impot Res2003; 15: 185. Google Scholar
- 11 : Natural history of prostatism: factors associated with discordance between frequency and bother of urinary symptoms. Urology1993; 42: 663. Google Scholar
- 12 : The prevalence of prostatism: a population-based survey of urinary symptoms. J Urol1993; 150: 85. Link, Google Scholar
- 13 : Association between smoking and erectile dysfunction: a population-based study. Am J Epidemiol2005; 161: 346. Google Scholar
- 14 : Cross-sectional associations of urogenital pain and sexual function in a community based cohort of older men: Olmsted County, Minnesota. J Urol2005; 174: 624. Link, Google Scholar
- 15 : Selective nitrergic neurodegeneration in diabetes mellitus—a nitric oxide-dependent phenomenon. Br J Pharmacol1999; 128: 1804. Google Scholar
- 16 : Impotence in diabetes mellitus. Diabetes Metab Rev1995; 11: 279. Google Scholar
- 17 : Erectile dysfunction is strongly linked with decreased libido in diabetic men. Aging Male2004; 7: 113. Google Scholar
- 18 : Erectile dysfunction in diabetic subjects in Italy: Gruppo Italiano Studio Deficit Erettile nei Diabetici. Diabetes Care1998; 21: 1973. Google Scholar
- 19 : New treatment options for erectile dysfunction in patients with diabetes mellitus. Drugs2004; 64: 2667. Google Scholar
- 20 : Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. JAMA1999; 281: 421. Google Scholar
- 21 : Erectile dysfunction in type 1 and type 2 diabetics in Italy: On behalf of Gruppo Italiano Studio Deficit Erettile nei Diabetici. Int J Epidemiol2000; 29: 524. Google Scholar
- 22 : The role of aging and chronic disease in sexual dysfunction. J Am Geriatr Soc1988; 36: 520. Google Scholar

