Abstract
Purpose:
We assessed the association between physical activity, and the risk of moderate and severe lower urinary tract symptoms.
Materials and Methods:
A cross-sectional representative sample of 30,377 men 45 to 79 years old in central Sweden who completed a self-administered life-style questionnaire, including International Prostate Symptom Score questions, physical activity currently and recalled at age 30 years (total, work/occupation, walking/bicycling, inactivity and exercise) and demographic data. A total of 6,905 men (23%) who scored 8 or more points on International Prostate Symptom Score questions were considered to have moderate or severe lower urinary tract symptoms.
Results:
After controlling for subject age, waist-to-hip ratio, diabetes, smoking and drinking status, and educational level total physical activity was significantly inversely related to moderate and severe lower urinary tract symptoms (highest vs lowest quartile OR 0.72, 95% CI 0.66 to 0.79, p trend <0.001). Men who were physically active at work as well as during leisure time were at half the risk of lower urinary tract symptoms compared to inactive men (OR 0.49, 95% CI 0.40 to 0.60). Long-term high inactivity (5 hours daily at age 30 years plus currently) was associated with a 2-fold increased risk compared with the risk in men who were more active at the 2 periods (OR 1.90, 95% CI 1.41 to 2.59).
Conclusions:
Our results suggest that physical activity in young and late adulthood may be associated with a lower risk of moderate and severe lower urinary tract symptoms.
References
- 1 : Health-related quality of life associated with lower urinary tract symptoms in four countries. Urology1998; 51: 428. Google Scholar
- 2 : Prevalence of lower urinary tract symptoms in men aged 45–79 years: a population-based study of 40 000 Swedish men. BJU Int2004; 94: 327. Google Scholar
- 3 : Obesity and benign prostatic hyperplasia. Am J Epidemiol1994; 140: 989. Google Scholar
- 4 : Hyperinsulinaemia as a risk factor for developing benign prostatic hyperplasia. Eur Urol2001; 39: 151. Google Scholar
- 5 : The development of benign prostatic hyperplasia among volunteers in the Normative Aging Study. Am J Epidemiol1985; 121: 78. Google Scholar
- 6 : Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol2005; 174: 1327. Link, Google Scholar
- 7 : Physical activity and benign prostatic hyperplasia. Arch Intern Med1998; 158: 2349. Google Scholar
- 8 : Life-style in patients with LUTS suggestive of BPH. Eur Urol, suppl.2001; 40: 9. Google Scholar
- 9 : Association of cigarette smoking, alcohol consumption and physical activity with lower urinary tract symptoms in older American men: findings from the third National Health And Nutrition Examination Survey. BJU Int2005; 96: 77. Google Scholar
- 10 : Risk factors for lower urinary tract symptoms in a population-based sample of African-American men. Am J Epidemiol2003; 157: 906. Google Scholar
- 11 : A prospective study of plasma hormone levels, nonhormonal factors, and development of benign prostatic hyperplasia. Prostate1995; 26: 40. Google Scholar
- 12 : Prostate cancer, benign prostatic hyperplasia and physical activity in Shanghai, China. Int J Epidemiol2001; 30: 341. Google Scholar
- 13 : Total physical activity in relation to age, body mass, health and other factors in a cohort of Swedish men. Int J Obes Relat Metab Disord2002; 26: 670. Google Scholar
- 14 : The American Urological Association symptom index for benign prostatic hyperplasia. J Urol1992; 148: 1549. Link, Google Scholar
- 15 : Validity and reproducibility of self-reported total physical activity—differences by relative weight. Int J Obes Relat Metab Disord2001; 25: 682. Google Scholar
- 16 : Does the mode of questionnaire administration affect the reporting of urinary symptoms?. Urology1995; 46: 341. Google Scholar
- 17 : The role of alpha1-adrenergic receptor subtypes in lower urinary tract symptoms. BJU Int, suppl.2001; 88: 27. Google Scholar
- 18 : Associations of obesity with lower urinary tract symptoms and noncancer prostate surgery in the Third National Health and Nutrition Examination Survey. Am J Epidemiol2004; 159: 390. Google Scholar
- 19 : Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA1998; 279: 669. Google Scholar
- 20 : The development of human benign prostatic hyperplasia with age. J Urol1984; 132: 474. Link, Google Scholar

