We have identified and partially characterized autoantibodies from the sera of patients with interstitial cystitis. Our characterization included initial screening by antinuclear antibody testing on human HEp-2 cell substrate and mouse kidney/stomach tissue substrate, titering and subtyping of positive sera, and Western blotting to identify target autoantigens. Of 96 interstitial cystitis patients 35 (36%) were positive for antinuclear antibodies at titers of 1/40 or greater. Among the antinuclear antibody patterns observed 24 were dense fine nuclear speckles, 7 were nucleolar, 3 were mitochondrial and 1 was coarse nuclear speckles. All but 4 of the antinuclear antibody positive sera were exclusively of the IgG class. As determined by unique antinuclear antibody staining patterns and by specificities on Western blots, interstitial cystitis autoantibodies appear to recognize novel autoantigens not previously described in patients with systemic autoimmune diseases, such as lupus, scleroderma and Sjogren’s syndrome.
© 1994 by The American Urological Association Education and Research, Inc.
- Cited byYang C, Burks D, Propert K, Mayer R, Peters K, Nickel J, Payne C, FitzGerald M, Hanno P, Chai T, Kreder K, Lukacz E, Foster H, Cen L, Landis J, Kusek J and Nyberg L (2011) Early Termination of a Trial of Mycophenolate Mofetil for Treatment of Interstitial Cystitis/Painful Bladder Syndrome: Lessons LearnedJournal of Urology, VOL. 185, NO. 3, (901-906), Online publication date: 1-Mar-2011.SAIRANEN J, FORSELL T and RUUTU M (2018) LONG-TERM OUTCOME OF PATIENTS WITH INTERSTITIAL CYSTITIS TREATED WITH LOW DOSE CYCLOSPORINE AJournal of Urology, VOL. 171, NO. 6 Part 1, (2138-2141), Online publication date: 1-Jun-2004.SUGAYA K, NISHIJIMA S, YAMADA T, MIYAZATO M, HATANO T and OGAWA Y (2018) Molecular Analysis of Adrenergic Receptor Genes And Interleukin-4/interleukin-4 Receptor Genes in Patients With Interstitial CystitisJournal of Urology, VOL. 168, NO. 6, (2668-2671), Online publication date: 1-Dec-2002.Leppilahti M, Tammela T, Huhtala H and Auvinen A (2018) Prevalence of Symptoms Related to Interstitial Cystitis in Women: A Population Based Study in FinlandJournal of Urology, VOL. 168, NO. 1, (139-143), Online publication date: 1-Jul-2002.PEEKER R, HAGHSHENO M, HOLMÄNG S and FALL M (2018) INTRAVESICAL BACILLUS CALMETTE-GUERIN AND DIMETHYL SULFOXIDE FOR TREATMENT OF CLASSIC AND NONULCER INTERSTITIAL CYSTITIS:: A PROSPECTIVE, RANDOMIZED DOUBLE-BLIND STUDYJournal of Urology, VOL. 164, NO. 6, (1912-1916), Online publication date: 1-Dec-2000.SHUPP BYRNE D, SEDOR J, ESTOJAK J, FITZPATRICK K, CHIURA A and MULHOLLAND S (2018) THE URINARY GLYCOPROTEIN GP51 AS A CLINICAL MARKER FOR INTERSTITIAL CYSTITISJournal of Urology, VOL. 161, NO. 6, (1786-1790), Online publication date: 1-Jun-1999.Keay S, Zhang C, Trifillis A, Hebel J, Jacobs S and Warren J (2018) Urine Autoantibodies in Interstitial CystitisJournal of Urology, VOL. 157, NO. 3, (1083-1087), Online publication date: 1-Mar-1997.
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© 1994 by The American Urological Association Education and Research, Inc.
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