A Double-Blind Crossover Study Evaluating the Efficacy of Korean Red Ginseng in Patients With Erectile Dysfunction: A Preliminary Report
We investigated the efficacy of Korean red ginseng for erectile dysfunction using the International Index of Erectile Function, RigiScan (UroHealth Systems, Laguna Niguel, California), hormonal levels and penile duplex ultrasonography with audiovisual sexual stimulation.
Materials and Methods:
A total of 45 patients with clinically diagnosed erectile dysfunction were enrolled in a double-blind, placebo controlled, crossover study (8 weeks on treatment, 2 weeks of washout and 8 weeks on treatment) in which the effects of Korean red ginseng and a vehicle placebo were compared using multiple variables. The ginseng dose was 900 mg. 3 times daily.
Mean International Index of Erectile Function scores were significantly higher in patients treated with Korean red ginseng than in those who received placebo (baseline 28.0 ± 16.7 and 38.1 ± 16.6 versus 30.9 ± 15.7, p <0.01). Scores on questions 3 (penetration) and 4 (maintenance) were significantly higher in the ginseng than in the placebo group (p <0.01). In response to the global efficacy question 60% of the patients answered that Korean red ginseng improved erection (p <0.01). Among other variables penile tip rigidity on RigiScan showed significant improvement for ginseng versus placebo.
Our data show that Korean red ginseng can be as effective alternative for treating male erectile dysfunction.
- 1 : Effect of ginseng on relaxation of penile corpus cavernosal smooth muscle in rabbits. J Urol1996; 155: 618A. abstract 1228. Google Scholar
- 2 : Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol1999; 58: 1685. Crossref, Medline, Google Scholar
- 3 : Ginsengs: a review of safety and efficacy. Nutr Clin Care2000; 3: 90. Crossref, Google Scholar
- 4 : Probable interaction between warfarin and ginseng. Am J Health Syst Pharm1997; 54: 692. Crossref, Medline, Google Scholar
- 5 : Key issues from the clinical trials of apomorphine SL. World J Urol2001; 19: 25. Crossref, Medline, Google Scholar
- 6 : Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. Int J Androl2000; 23: 82. Crossref, Medline, Google Scholar
- 7 : A review of 12 commonly used medicinal herbs. Arch Fam Med1998; 7: 523. Crossref, Medline, Google Scholar
- 8 : Panax ginseng pharmacology: a nitric oxide link?. Biochem Pharmacol1997; 54: 1. Crossref, Medline, Google Scholar
- 9 : Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol1995; 115: 15. Crossref, Medline, Google Scholar
- 10 : Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle. Int J Impot Res1998; 10: 37. Crossref, Medline, Google Scholar
- 11 : Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impot Res1995; 7: 181. Medline, Google Scholar
- 12 : Effects of Panax Ginseng root on conditioned avoidance response in rats. Jpn J Pharmacol1977; 27: 509. Crossref, Medline, Google Scholar
- 13 : A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol1986; 16: 15. Crossref, Medline, Google Scholar
- 14 : Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med1985; 3: 221. Crossref, Google Scholar
- 15 : Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors. Gen Pharmacol1994; 25: 193. Crossref, Medline, Google Scholar
From the Department of Urology, University of Ulsan College of Medicine, Asan Medical Center and Korea Ginseng and Tobacco Research Institute, Seoul, Korea